Semax 10mg Spray

Semax 10mg Spray contains Semax, a synthetic seven-amino-acid peptide developed from a fragment of adrenocorticotropic hormone (ACTH). Its structure combines ACTH(4-7) with a Pro-Gly-Pro (PGP) sequence, producing the heptapeptide Met-Glu-His-Phe-Pro-Gly-Pro.

Semax has been investigated primarily in neurological research, with studies examining neurotrophic signalling, gene expression, cerebral ischaemia and pathways associated with learning and memory. Particular research interest surrounds its relationship with brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and the TrkB receptor.

What Is Semax?

Semax is a synthetic analogue derived from the N-terminal region of ACTH. The first four amino acids, Met-Glu-His-Phe, correspond to ACTH(4-7), while the Pro-Gly-Pro sequence forms the C-terminal portion of the molecule.

The resulting seven-amino-acid sequence is:

Met-Glu-His-Phe-Pro-Gly-Pro

The addition of the PGP sequence is an important structural feature and helps distinguish Semax from the naturally occurring ACTH fragment on which it was based.

Despite its relationship with ACTH, Semax research is primarily centred on neurological rather than adrenal pathways.

Why Is Semax Researched?

One of the most established areas of Semax research concerns neurotrophins. These are signalling proteins involved in neuronal survival, development and synaptic plasticity.

Animal research has shown that Semax can alter expression of both BDNF and NGF in different regions of the brain. Separate experiments have also identified changes involving TrkB, the receptor through which BDNF produces many of its cellular effects.

These findings have provided researchers with a molecular basis for investigating Semax beyond general descriptions of cognitive performance.

Semax, BDNF And TrkB

BDNF is an important neurotrophin involved in neuronal plasticity and the ability of neural connections to adapt in response to activity and environmental changes.

In one rat study, Semax produced a maximum 1.4-fold increase in hippocampal BDNF protein alongside a 1.6-fold increase in TrkB phosphorylation. Researchers also observed approximately three-fold and two-fold increases in particular BDNF and TrkB mRNA measurements, respectively.

Other experiments have found that the response is both time-dependent and region-specific. Changes in BDNF and NGF expression have been observed in areas including the hippocampus, frontal cortex, brainstem and cerebellum.

This BDNF/TrkB relationship is one of the more clearly characterised molecular pathways associated with Semax research.

Cerebral Ischaemia Research

Another distinct research area involves cerebral ischaemia, where blood flow and oxygen supply to brain tissue are disrupted.

Animal models of cerebral ischaemia have shown that Semax can influence the transcription of neurotrophins and their receptors following injury. Research has also examined genes and proteins associated with inflammatory response, neurotransmission, cellular stress and neuronal recovery.

For example, studies in rat models have reported changes involving BDNF, NGF, Trk receptors, CREB, MMP-9 and JNK following Semax exposure.

These findings provide several different molecular targets for continued neurological research rather than suggesting that Semax acts through one isolated mechanism.

What Other Areas Are Being Studied?

The Semax literature extends into several other areas of neuroscience.

• Learning and memory: Experimental studies have examined behavioural changes alongside neurotrophic signalling in the hippocampus.
• Gene expression: Transcriptomic research has identified changes across groups of genes involved in neurotransmission, immune response and cellular signalling.
• Neuronal survival: Cell and animal models have investigated responses to hypoxia, ischaemia and other forms of neurological stress.
• Metal interactions: Semax has demonstrated an ability to coordinate copper ions, with separate laboratory work examining how these complexes influence metal-associated cellular toxicity.

Much of the detailed mechanistic evidence comes from cell and animal research. Results from these models should not automatically be interpreted as established cognitive or neurological benefits in humans.

Spray Format & Storage

Semax 10mg Spray is supplied as a prepared spray formulation for controlled laboratory research.

Maintain the product according to the refrigerated storage conditions specified for the formulation. Protect it from excessive heat and direct light, and minimise unnecessary temperature changes during storage.

Disclaimer: This product is supplied strictly for laboratory research purposes only. Not for human or animal consumption.